IIMMUNOASSAYS:
environmental agents
foodborne pathogens
infectious diseases
autoimmune biomarkers
oncology biomarkers
Luminescence
detection technologies
and dedicated
luminometer
instrument systems
and software
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TECHNOLOGY
ASDx Biosystems integrates biomolecular detection systems to advance the development, testing and deployment of critical technologies to address biothreat, infectious agent, autoimmune and oncology applications. Peptide epitope biomarker detection reagents combined with glow kinetic detection reagents and luminometer instrument technologies are combined to produce the highest quality luminescence immunoassays and detection platforms.
Robust, sensitive and specific assays with the advantages of glow luminescence are being developed and optimized for both portable and benchtop high performance tube luminometers or higher throughput microplate luminometers from leading manufacturers.
Reliance on photon counting ensures that the same conditions are used for every measurement during a luminometer's life time and thereby reduces experimental error due to calibration requirements. In addition, fast photon counting circuitry can provide a dynamic range of six orders of magnitude.
ASDx Biosystems works with vendors and testing laboratories around the world to provide complete systems integrating consumables, reagents, hardware and software.
Technology Application Resources
Stanker LH, Merrill P, Scotcher MC, Cheng LW (2008) Development and partial characterization of high-affinity monoclonal antibodies for botulinum toxin type A and their use in analysis of milk by sandwich ELISA. J Immunol Methods 336:1-8.
McBride JD, Gabriel FG, Fordham J, Kolind T, Barcenas-Morales G, Isenberg DA, Swana M, Delves PJ, Lund T, Cree IA, Roitt IM (2008) Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray using a filtration-assisted Nanodot Array Luminometric ImmunoAssay (NALIA). Clinical Chemistry 54:883-890.
Patel JI, Saleh GM, Hykin PG, Gregor ZJ, Cree IA (2008) Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy. Eye 22: 223-8.
Patel JI, Tombran-Tink J, Hykin PG, Gregor ZJ, Cree IA (2006) Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles. Experimental Eye Research 82: 798-806.
Patel JI, Hykin PG, Cree IA (2006) Diabetic cataract removal: postoperative progression of maculopathy growth factor and clinical analysis. British Journal of Ophthalmology 90: 697-701.
Kricka LJ (2003) Clinical applications of chemiluminescence. Analytica Chimica Acta 500:279-286.
Tu S-I, Golden M, Andreotti PE, and Irwin P (2002) The use of time-resolved fluoroimmunoassay to simultaneously detect Escherichia coli O157:H7, Salmonella typhimurium and Salmonella enteriditis in foods. Journal of Rapid Methods and Automation in Microbiology, v10. P37-48.
Andreotti PE, Meyer R, Campbell T, Goode MT, Menking DL, Myers ED, Palenius T, and Stanker L (2001) Detection and identification of animal and food pathogens using time-resolved fluorescence. Photonic Detection and Intervention Technologies for Safe Food. Yud-Ren Chen and Shu-I Tu, eds. Proceedings of SPIE. 4206: 4857.
Andreotti PE and Berthold F (1999) Application of a new high sensitivity luminometer for industrial microbiology and molecular biology. Luminescence 14(1):19-22. |
